Honestly, in my opinion, every OS should have a folder or drive simply called "Trusted" on it.
C:\Trusted\ or T:\ for trusted, or whatever someone wants to set things up for.
Then, when you go to a site and you trust the software on it, you simply download it to C:\Trusted\Trusted Downloads\ and then extract it to to C:\Trusted\Programs, and the built in anti-virus never once reads/scans/or checks it for you. YOU, as the human and owner of the PC, have declared it to be a trusted program and your anti-virus can go take a hike and pisser off.
Nothing is more of a PITA than to download a file and then have some keygen or crack which is *SUPPOSED* to be there for your pirated software to work properly, just up and quarantine even before you ever open it to start with. Nothing is more annoying than compiling your own damn code and then having the OS quarantine it half a second after it compiles and then you'll blaming the compiler saying, "it didn't really compile"!! Most of the anti-viruses nowadays do their own thing and they do them silently in the background, with you only finding out what's going on if you open them and check status/update/actions/whatever tab they hide it under.
Personally, I don't even have *any* anti-virus running on my machine. Nor firewall. My UAC settings are as low as any system will allow. I don't want my damn PC to protect me from myself. IF I SCREW UP LIKE AN IDIOT AND INFECT MY MACHINE, I'LL REINSTALL WINDOWS MYSELF AND FIX IT!!!
As far as I'm concerned, false positives and unwanted quarantines, and blocking of permissions and the ability to use my own damn PC to do and run what *I* want to do and run, makes an anti-virus much more of an issue than any virus which is out there waiting for me to stumble upon it. I simply don't download suspicious files. If I ever do, it's always in a sandbox first, and then I wait and watch to see what happens. I don't click those "You are the 1000th visitor to this site and win a BLAH!!" popups. I expect to keep myself safe, any the antivirus on my machine is just more of a pain than it is a boon, and it consumes so much resources and CPU and runtime and then 99.987% of the time just gives me ISSUES to deal with instead of any real benefit...
So I just don't use any anti-virus at all.
For everyone else, I *at least* recommend setting up your system with one safe zone for all your stuff which is never exposed to any anti-virus/firewall shenanigans. Make a C:\Trusted folder and whitelist it. Exempt it. Put all your coding stuff and personal stuff that you download and trust in it.
Your life will be SOOOOO much better afterwards for it. And if you ever *do* get a virus there.... Shrug it off and just accept that YOU were the one who trusted something like an idiot that you shouldn't have. Learn, don't trust such things again, and reinstall windows/OS and go from there.